Hypodermoclysis in patients under palliative care: new pharmaceutical recommendations for clinical practice
Main Article Content
Abstract
Palliative care (PC) is defined by the World Health Organization as an approach that improves the quality of life of patients and their families facing problems associated with life-threatening illnesses. Hypodermoclysis (HDC) is considered the second main route of administration for patients undergoing PC and is mainly recommended in cases of impossibility of oral ingestion and difficult venous access. As it is considered an old practice, more medications are being tested and recommended for use via HDC. The pharmacist is the professional responsible for answering questions related to medicines and may not be properly updated and qualified on the topic. The objective of this work was to describe the new pharmaceutical recommendations for the use of medications and fluids through HDC. The review was carried out in the Medline databases; Embase; Cochrane Database; Latin American Literature in Health Sciences and Scientific Electronic Library Online, including publications in any language from 2015 onwards. The exclusion criteria was articles on HDC in pediatric PC and articles that contain only technical information involving this route. The search resulted in 872 articles. Of these, 67 were fully analyzed, 42 of which were included. The summary of the new pharmaceutical recommendations regarding the administration of medications and fluids via HDC can help guide this professional in clarifying doubts and making evidence-based decisions, promoting the optimization of pharmacotherapy for patients under PC.
Downloads
Article Details

This work is licensed under a Creative Commons Attribution 4.0 International License.
• The author (s) warrant that the contribution is original and unpublished and that it is not in the process of being evaluated in other journal (s);
• The journal is not responsible for the opinions, ideas and concepts issued in the texts, as they are the sole responsibility of the author (s);
• Publishers have the right to make textual adjustments and to adapt the article to the rules of publication.
Authors retain the copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which allows the sharing of work with acknowledgment of authorship and initial publication in this journal.
Authors are authorized to take additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (eg publish in institutional repository or as book chapter), with acknowledgment of authorship and initial publication in this journal.
Authors are allowed and encouraged to publish and distribute their work online (eg in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase the impact and citation of the published work (See The Effect of Free Access) at http://opcit.eprints.org/oacitation-biblio.html
References
ARMSTRONG, P.; WILKINSON, P.; MCCORRY, N. K. Use of parecoxib by continuous subcutaneous infusion for cancer pain in a hospice population. BMJ Supportive & Palliative Care, v. 8, n. 1, p. 25–29, 1 set. 2017.
AZHAR, M. Retrospective analysis of phenobarbitone prescribing in palliative patients in the acute hospital setting. Palliative Medicine, v. 35, n.1, p. 77. 2021.
BIRCH, F. et al. “Subcutaneous furosemide in advanced heart failure: service improvement project”. BMJ Supportive & Palliative Care, v. 13, n. 1, p. 112-116. 2023.
BOSCH, E. M.; FUENSANTA, S. R.; CATALINA, B. O. Determination of compatibility and stability of haloperidol and morphine mixtures used in palliative care. Brazilian Journal of Pharmaceutical Sciences, v. 54, n. 2, 26 jul. 2018.
BROWN, A. et al. Furosemide in end-stage heart failure: community subcutaneous infusions. BMJ Supportive & Palliative Care, v. 12, n. 6, p. 763-766. 2022.
CAMPBELL, A.; RAWLINSON, F.; GADOUD, A. 183 How are specialist palliative care units using ranitidine in the medical management of adults with malignant bowel obstruction? A survey of UK hospices. BMJ Supportive & Palliative Care, v. 10, n.1, p. 72-73. 2020.
COOP, H.; PAULSON, R. CLINICAL AND ECONOMIC EVALUATION OF SOMATOSTATIN DEPOT TO SUPPORT SYMPTOM MANAGEMENT IN PALLIATIVE CARE. BMJ Supportive & Palliative Care, v. 12, n. 2, p. 57-58. 2022.
DAVIS, C. et al. Sodium valproate subcutaneous infusion; a valuable adjunct in the management of neuropathic pain in palliative patients. BMJ Supportive & Palliative Care, v. 8, p. 48. 2018.
DÍAZ, S. DEL P. et al. Perfusión de furosemida subcutánea como tratamiento paliativo en insuficiencia cardíaca refractaria. Revista Colombiana de Cardiología, v. 27, n. 1, p. 44–48, 1 fev. 2020.
EBISUI, Y.; OKAMURA, N.; ITANO T. A retrospective investigation of low dose oxycodone injection in opioid naive elderly terminal cancer patients. Annals of Oncology, v. 27, n. 7, p. 101. 2016.
FENNING, S. J. et al. Subcutaneous magnesium in the advanced cancer setting. BMJ Supportive & Palliative Care, v. 8, n. 2, p. 191–193, 23 jun. 2017.
FREIHERR, W. V. H. et al. Use of dexmedetomidine continuous subcutaneous infusion (CSCI) in a palliative care service in Ireland. Palliative Medicine, v. 30, n. 6, p. 85. 2016.
FÜRST, P. et al. Continuous subcutaneous infusion for pain control in dying patients: experiences from a tertiary palliative care center. BMC Palliative Care, v. 19, n. 1, 10 nov. 2020.
FURTADO, I. et al. Continuous subcutaneous levetiracetam in end-of-life care. BMJ Case Reports, p. bcr-2017-222340, 18 jan. 2018.
FUTAMI S. et al. Effect of subcutaneous oxycodone for end-stage heart failure due to severe aortic stenosis — A case report. Journal of Cardiology Cases, v. 17, n. 6, p. 187–189, 1 jun. 2018.
GONÇALVES, J. A. F. et al. Use of Alfentanil in Palliative Care. Pharmacy, v. 8, n. 4, p. 240, 16 dez. 2020.
HERNDON, C. M. et al. ASHP Guidelines on the Pharmacist’s Role in Palliative and Hospice Care. American Journal of Health-System Pharmacy, v. 73, n. 17, p. 1351–1367, 1 set. 2016.
HINDMARSH, J. et al. Administering Neostigmine as a Subcutaneous Infusion: A Case Report of a Patient Dying With Myasthenia Gravis. J Palliat Care, v. 35, n. 2, p. 78-81, 2020. DOI: 10.1177/0825859719869353.
HINDMARSH, J. et al. Administering esomeprazole subcutaneously via a syringe driver in the palliative demographic: A case series. Journal of Clinical Pharmacy and Therapeutics, v. 47, n. 5, p. 694–698, 27 dez. 2021.
HINDMARSH, J. et al. Subcutaneous Olanzapine at the End of Life in a Patient with Schizophrenia and Dysphagia. Palliative medicine reports, v. 1, n. 1, p. 72–75, 1 jun. 2020.
HOGG, R. et al. CASE REPORT: SUBCUTANEOUS TRANEXAMIC ACID ADMINISTRATION VIA A CONTINUOUS INFUSION SUCCESSFULLY CONTROLLED BLEEDING AT END OF LIFE. BMJ Supportive & Palliative Care, v. 12, n. 2, p. 36. 2022.
HOWARD, P.; CURTIN, J. Bleeding management in palliative medicine: subcutaneous tranexamic acid - retrospective chart review. BMJ Supportive & Palliative Care, v. 0, p. 1-5. 2022.
HOWARD, P.; CURTIN, J. Efficacy and safety of subcutaneous clonidine for refractory symptoms in palliative medicine: a retrospective study. BMJ Supportive & Palliative Care, v. 0, p. 1-5. 2022.
JANSSEN, D. J. A. et al. COVID-19: guidance on palliative care from a European Respiratory Society international task force. European Respiratory Journal, v. 56, n. 3, 1 set. 2020.
KHOURY, J. E. et al. Evaluation of efficacy and safety of subcutaneous acetaminophen in geriatrics and palliative care (APAPSUBQ). BMC Palliative Care, v. 21, n. 1, 26 mar. 2022.
KIANI, C. S.; HUNT, R. W. Lidocaine Continuous Subcutaneous Infusion for Neuropathic Pain in Hospice Patients: Safety and Efficacy. Journal of Pain & Palliative Care Pharmacotherapy, v. 35, n. 1, p. 52–62, 2 jan. 2021.
KONDASINGHE, J. S. et al. Subcutaneous Levetiracetam and Sodium Valproate Use in Palliative Care Patients. Journal of Pain & Palliative Care Pharmacotherapy, p. 1–5, 5 ago. 2022.
MAKOWSKY, M. J.; BELL, P.; GRAMLICH, L. Subcutaneous Magnesium Sulfate to Correct High-Output Ileostomy-Induced Hypomagnesemia. Case Reports in Gastroenterology, v. 13, n. 2, p. 280–293, 26 jun. 2019.
MENDIS, R. et al. Palliative care and COVID-19 in the Australian context: a review of patients with COVID-19 referred to palliative care. Australian Health Review, n. 45, p. 667-674. 2021.
MICHELON, H. et al. Subcutaneous pantoprazole in an elderly, palliative care patient. BMJ Supportive & Palliative Care, v. 12, p. 187-188, 28 ago. 2019.
MURRAY-BROWN, F. L.; STEWART, A. Remember Keppra: seizure control with subcutaneous levetiracetam infusion. BMJ Supportive & Palliative Care, v. 6, n. 1, p. 12–13, 25 jan. 2016.
MYLES, H.; CRANFIELD, F. P-119 Use of BACLOFEN in a continuous subcutaneous infusion. BMJ Supportive & Palliative Care, v. 7, p. 44. 2017.
O’CONNOR, N.; HAYDEN, C.; O’LEARY, N. Sodium Valproate as a Continuous Subcutaneous Infusion: A Case Series. Journal of Pain and Symptom Management, v. 54, n. 2, p. 1–e, ago. 2017.
PAPA, P. et al. Pharmacokinetics of Subcutaneous Levetiracetam in Palliative Care Patients. Journal of Palliative Medicine, v. 24, n. 2, p. 248–251, 1 fev. 2021.
RAMDANY, H.; CURTIN, J.; HOWARD, P. Zoledronic acid by subcutaneous infusion in palliative medicine. BMJ Supportive & Palliative Care, p. 1-2, 13 set. 2022.
ROUBAUD-BAUDRON, C. et al. Tolerance of subcutaneously administered antibiotics: a French national prospective study. Age and Ageing, v. 46, p. 151-155, 8 set. 2016.
SÁNCHEZ, M. P. et al. Uso paliativo de la furosemida en infusión continua subcutánea en un paciente trasplantado renal con fallo cardíaco. Nefrologia, v. 38, n. 4, p. 438–439, 1 jul. 2018.
SANCHO, M. G. et al. Cuidados Paliativos: Control de Síntomas. Las Palmas de Gran Canaria: Unidad de Medicina Paliativa, Hospital Universitario de Gran Canaria Dr. Negrín. Espanha. 2014. Disponível em: <https://paliativos.uy/wp-content/uploads/2018/08/Libro-CONTROL-DE-SINTOMAS-EN-CUIDADOS-PALIATIVOS-MINISTERIO-DE-SALUD-1.pdf>
SAURA, V. S. et al. Levetiracetam in continuous subcutaneous infusion at the end of life. Medicina Paliativa, v. 27, n. 1, p. 58-62. 2020.
SEAH, D. S. E. et al. Subcutaneous Lidocaine Infusion for Pain in Patients with Cancer. Journal of Palliative Medicine, v. 20, n. 6, p. 667–671, jun. 2017.
Sociedade Brasileira de Geriatria e Gerontologia. O uso da via subcutânea em geriatria e cuidados paliativos: Um guia da SBGG e da ANCP para profissionais. 2ª ed. Rio de Janeiro: SBGG, 2017. 60p.
THOMAS, B. et al. Dexmedetomidine for hyperactive delirium at the end of life: An open-label single arm pilot study with dose escalation in adult patients admitted to an inpatient palliative care unit. Palliative Medicine, v. 35, n. 4, p. 729–737, 17 fev. 2021.
TWIGGER, S. et al. 170 The use of subcutaneous levetiracetam in the west midlands’ palliative care population: a retrospective audit. BMJ Supportive & Palliative Care, v. 8, n. 1, p. A71–A72, 1 mar. 2018.
USACH, I. et al. Subcutaneous Injection of Drugs: Literature Review of Factors Influencing Pain Sensation at the Injection Site. Advances in Therapy, v. 36, n. 11, p. 2986–2996, 5 out. 2019.
VANDEVELDE, C.; HO, J. Subcutaneous Infusion of Pamidronate in a Hospice Patient with Hypercalcemia: A Case Report. The Canadian Journal of Hospital Pharmacy, v. 74, n. 1, 15 jan. 2021.
WOODMAN, M.; CURTIN, J.; HOWARD, P. Esomeprazole for subcutaneous infusion: compatibility with other alkaline medications. BMJ Supportive & Palliative Care, p. 1-3, 13 set. 2022.
WORLD HEALTH ORGANIZATION (WHO). National cancer control programmes: policies and managerial guidelines. 2.ed. Geneva: WHO, 2002.
WORLDWIDE HOSPICE PALLIATIVE CARE ALLIANCE. Global Atlas of Palliative Care. 2º ed. Londres, 2020. 120 pg.
ZALOGA, G. P. et al. Safety and Efficacy of Subcutaneous Parenteral Nutrition in Older Patients: A Prospective Randomized Multicenter Clinical Trial. Journal of Parenteral and Enteral Nutrition, v. 41, n. 7, p. 1222–1227, 17 fev. 2016.
ZAMORA, M. A. S. et al. Tolerability and effectiveness of levetiracetam and midazolam in subcutaneous continuous infusion: Case report. Medicina Paliativa. v. 26, n. 3, p. 254-256, 2019.