Polylactic acid scaffolds obtained by 3D printing and modified by oxygen plasma

Main Article Content

Lorenzo Gouvêa Machado
Mayté Paredes Zaldivar
Mônica Rosas da Costa Iemma
Sandra Andrea Cruz
Elidiane Cipriano Rangel
Eduardo José Nassar
Hernane Silva Barud

Resumo

The purpose of tissue engineering is to repair, replace, and regenerate tissues and organs. For this aim, materials supports, as polylactic acid (PLA) are used. PLA is a thermoplastic polymer that presents biodegradability, biocompatibility and good processability. PLA scaffolds can accurately constructed by 3D printing. Then, the objectives of this work were to modify the hydrophobic surface of PLA scaffolds using oxygen plasma and to study the cell viability and proliferation. The characterization was done by AFM, contact angle, FTIR and studies of proliferation and cell viability. Results showed that the material acquired hydrophilic properties by the presence of oxygen reactive species and by contact angle decrease. It was also observed an increase in the surface roughness. We can conclude that although the surface modifications were effective and the PLA scaffolds were not cytotoxic, there were no improvements in the proliferation process with the studied osteo-1 lineage cells. 

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Machado, L. G., Zaldivar, M. P., Iemma, M. R. da C., Cruz, S. A., Rangel, E. C., Nassar, E. J., & Barud, H. S. (2020). Polylactic acid scaffolds obtained by 3D printing and modified by oxygen plasma. Revista Brasileira Multidisciplinar - ReBraM, 23(1), 97-106. https://doi.org/10.25061/2527-2675/ReBraM/2020.v23i1.813
Seção
Artigos Originais
Biografia do Autor

Lorenzo Gouvêa Machado, University of Araraquara - UNIARA

Biopolymers and Biomaterials Research Group - BIOPOLMAT

Mayté Paredes Zaldivar, University of Araraquara - UNIARA

Biopolymers and Biomaterials Research Group - BIOPOLMAT

Mônica Rosas da Costa Iemma, University of Araraquara - UNIARA

Biopolymers and Biomaterials Research Group - BIOPOLMAT

Sandra Andrea Cruz, Federal University of São Carlos - UFSCAR

Department of Chemistry, Center for Exact Sciences and Technology

Elidiane Cipriano Rangel, Sorocaba Institute of Science and Technology. Paulista State University- UNESP

Plasma and Materials Group

Eduardo José Nassar, University of Franca - UNIFRAN

PhD in Chemistry from the University of São Paulo- Researcher

Hernane Silva Barud, University of Araraquara - UNIARA

Biopolymers and Biomaterials Research Group - BIOPOLMAT

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