Tratamentos naturais para controle da ansiedade: revisão crítica de ensaios clínicos randomizados e quase randomizados
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Objetivo: Evaluar tratamientos naturales incorporados a la medicina complementaria, alternativa e integrativa para el control de los trastornos de ansiedad (TA) a través de una revisión crítica de ensayos clínicos aleatorizados y cuasialeatorizados. Materiales y métodos: Se utilizaron cinco bases de datos electrónicas según los criterios de elegibilidad. Luego de eliminar duplicados y leer títulos y resúmenes, los datos fueron tabulados en Excel® 2016 y VantagePoint™. Se realizó un análisis descriptivo de las variables tipo de tratamiento, grupo de edad, presentación del fármaco, producto natural, eficacia y efectos adversos, revista y su factor de impacto, número de citas en las bases de datos Scopus y Google Scholar. Resultados: Treinta estudios fueron incluidos. El estudio más citado tiene 337 citas en Google Scholar y 192 en Scopus. De los tratamientos, 28 (93,33%) fueron fitoterápicos, uno (3,33%) homeopático y uno (3,33%) remedios florales. Quince estudios se realizaron en adultos, 14 en adultos y ancianos y uno en adolescentes. Cápsula (n=18), pastilla (n=6) y solución (n=1) fueron las presentaciones de los medicamentos, con efecto positivo clínicamente probado (n=25; 83%). Se han informado náuseas, mareos, dolores de cabeza y somnolencia. Piper methysticum, Matricaria recutita, Ginkgo biloba, Passiflora incarnata, Withania somnifera y Centella asiatica fueron los productos naturales estudiados. Conclusión: Los tratamientos naturales incorporados a la medicina complementaria, alternativa e integrativa para el control de la de han sido publicados en los últimos 24 años, especialmente en países desarrollados y en revistas con variado factor de impacto. La fitoterapia es el tipo de tratamiento más utilizado para la disfunción eréctil y sus efectos positivos han sido clínicamente probados.
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Referencias
Amsterdam, J. D., Li, Q. S., Xie, S. X., & Mao, J. J. (2020). Putative antidepressant effect of chamomile (Matricaria chamomilla L.) oral extract in subjects with comorbid generalized anxiety disorder and depression. The Journal of Alternative and Complementary Medicine, 26(9), 815-821.
Amsterdam, J. D., Li, Y., Soeller, I., Rockwell, K., Mao, J. J., & Shults, J. (2009). A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol, 29(4), 378-382. doi: 10.1097/JCP.0b013e3181ac935c
APA , A. P. A. (2013). Diagnostic and statistical manual of mental disorders: DSM-5. United States.
Baker, D. G., Myers, S. P., Howden, I., & Brooks, L. (2003). The effects of homeopathic Argentum nitricum on test anxiety. Complement Ther Med, 11(2), 65-71.
Bhattacharyya, D., Sur, T., Jana, U., & Debnath, P. (2008). Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll J, 10(3), 176-179.
Bourin, M., Bougerol, T., Guitton, B., & Broutin, E. (1997). A combination of plant extracts in the treatment of outpatients with adjustment disorder with anxious mood: controlled study versus placebo. Fundam Clin Pharmacol, 11(2), 127-132.
Bystritsky, A., Kerwin, L., & Feusner, J. D. (2008). A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med, 14(2), 175-180. doi: 10.1089/acm.2007.7117
Carmona, F., Coneglian, F. S., Batista, P. A., Aragon, D. C., Angelucci, M. A., Martinez, E. Z., & Pereira, A. M. S. (2019). Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) powdered leaves are effective in treating anxiety symptoms: A phase-2, randomized, placebo-controlled clinical trial. Journal of ethnopharmacology, 242, 112060.
Colalto, C. (2018). What phytotherapy needs: Evidence-based guidelines for better clinical practice. Phytother Res, 32(3), 413-425. doi: 10.1002/ptr.5977
Combs, H., & Markman, J. (2014). Anxiety disorders in primary care. Medical Clinics, 98(5), 1007-1023.
Connolly, S. D., & Bernstein, G. A. (2007). Practice parameter for the assessment and treatment of children and adolescents with anxiety disorders. Journal of the American Academy of Child & Adolescent Psychiatry, 46(2), 267-283.
Connor, K. M., & Davidson, J. R. (2002). A placebo-controlled study of Kava kava in generalized anxiety disorder. Int Clin Psychopharmacol, 17(4), 185-188. doi: 10.1097/00004850-200207000-00005
Contatore, O. A., Tesser, C. D., & Barros, N. F. d. (2018). Chinese medicine/acupuncture: historical notes on the colonization of a body of knowledge. História, Ciências, Saúde-Manguinhos, 25(3), 841-858.
Donthu, N., Kumar, S., Mukherjee, D., Pandey, N., & Lim, W. M. (2021). How to conduct a bibliometric analysis: An overview and guidelines. Journal of Business Research, 133, 285-296.
Ernst, E. (2010). Bach flower remedies: a systematic review of randomised clinical trials. Swiss Med Wkly, 140, w13079. doi: 10.4414/smw.2010.13079
Fajemiroye, J. O., da Silva, D. M., de Oliveira, D. R., & Costa, E. A. (2016). Treatment of anxiety and depression: medicinal plants in retrospect. Fundam Clin Pharmacol, 30(3), 198-215. doi: 10.1111/fcp.12186
Fuladi, S., Emami, S. A., Mohammadpour, A. H., Karimani, A., Manteghi, A. A., & Sahebkar, A. (2020). Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Current clinical pharmacology.
Gastpar, M., & Klimm, H. (2003). Treatment of anxiety, tension and restlessness states with Kava special extract WS® 1490 in general practice: A randomized placebo-controlled double-blind multicenter trial. Phytomedicine, 10(8), 631-639.
Hanus, M., Lafon, J., & Mathieu, M. (2004). Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Current medical research and opinion, 20(1), 63-71.
Jana, U., Sur, T., Maity, L., Debnath, P., & Bhattacharyya, D. (2010). A clinical study on the management of generalized anxiety disorder with Centella asiatica. Nepal Med Coll J, 12(1), 8-11.
Kasper, S., Gastpar, M., Müller, W. E., Volz, H.-P., Möller, H.-J., Dienel, A., & Schläfke, S. (2010). Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’anxiety disorder: a randomized, double-blind, placebo controlled trial. Int Clin Psychopharmacol, 25(5), 277-287.
Kasper, S., Möller, H.-J., Volz, H.-P., Schläfke, S., & Dienel, A. (2017). Silexan in generalized anxiety disorder: investigation of the therapeutic dosage range in a pooled data set. Int Clin Psychopharmacol, 32(4), 195-204.
Keefe, J. R., Mao, J. J., Soeller, I., Li, Q. S., & Amsterdam, J. D. (2016). Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder. Phytomedicine, 23(14), 1699-1705.
Kobak, K. A., vH Taylor, L., Warner, G., & Futterer, R. (2005). St. John's wort versus placebo in social phobia: results from a placebo-controlled pilot study. Journal of Clinical Psychopharmacology, 25(1), 51-58.
Kuchta, K., de Nicola, P., & Schmidt, M. (2018). Randomized, dose‐controlled double‐blind trial: Efficacy of an ethanolic kava (Piper methysticum rhizome) extract for the treatment of anxiety in elderly patients. Traditional & Kampo Medicine, 5(1), 3-10.
Kupfer, D. J. (2015). Anxiety and DSM-5. Dialogues in clinical neuroscience, 17(3), 245.
Lakhan, S. E., & Vieira, K. F. (2010). Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Nutrition journal, 9, 42-42. doi: 10.1186/1475-2891-9-42
Leonti, M., & Verpoorte, R. (2017). Traditional Mediterranean and European herbal medicines. J Ethnopharmacol, 199, 161-167. doi: 10.1016/j.jep.2017.01.052
Li, F. S., & Weng, J. K. (2017). Demystifying traditional herbal medicine with modern approach. 3, 17109. doi: 10.1038/nplants.2017.109
Lopresti, A. L., Drummond, P. D., Inarejos-García, A. M., & Prodanov, M. (2018). Affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: a randomised, double-blind, placebo-controlled study. Journal of affective disorders, 232, 349-357.
Mao, J. (2016). Long-term chamomile for generalized anxiety disorder: A randomized controlled trial. J. Altern. Complement. Med., Volume 22(Issue 6), A59
Mao, J. J., Xie, S. X., Keefe, J. R., Soeller, I., Li, Q. S., & Amsterdam, J. D. (2016). Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Phytomedicine, 23(14), 1735-1742.
Mazidi, M., Shemshian, M., Mousavi, S. H., Norouzy, A., Kermani, T., Moghiman, T., . . . Ferns, G. A. (2016). A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J Complement Integr Med, 13(2), 195-199. doi: 10.1515/jcim-2015-0043
Nematolahi, P., Mehrabani, M., Karami-Mohajeri, S., & Dabaghzadeh, F. (2018). Effects of Rosmarinus officinalis L. on memory performance, anxiety, depression, and sleep quality in university students: A randomized clinical trial. Complement Ther Clin Pract, 30, 24-28.
Organization, W. H. (2004). Promoting mental health: Concepts, emerging evidence, practice: Summary report: World Health Organization.
Park, D.-M., Kim, S.-H., Park, Y.-C., Kang, W.-C., Lee, S.-R., & Jung, I.-C. (2014). The comparative clinical study of efficacy of Gamisoyo-San (Jiaweixiaoyaosan) on generalized anxiety disorder according to differently manufactured preparations: multicenter, randomized, double blind, placebo controlled trial. Journal of ethnopharmacology, 158, 11-17.
Pilkington, K., Kirkwood, G., Rampes, H., Fisher, P., & Richardson, J. (2006). Homeopathy for anxiety and anxiety disorders: a systematic review of the research. Homeopathy, 95(3), 151-162. doi: 10.1016/j.homp.2006.05.005
Posadzki, P., Watson, L. K., & Ernst, E. (2013). Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med (Lond), 13(1), 7-12. doi: 10.7861/clinmedicine.13-1-7
Primi, R. (2010). Psychological assessment in Brazil: foundations, current situation and future directions. Psicologia: Teoria e Pesquisa, 26, 25-35.
Ravindran, A. V., Balneaves, L. G., Faulkner, G., Ortiz, A., McIntosh, D., Morehouse, R. L., . . . Group, C. D. W. (2016). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 5. Complementary and Alternative Medicine Treatments. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 61(9), 576-587. doi: 10.1177/0706743716660290
Ross, S. M. (2013). Generalized anxiety disorder (GAD): efficacy of standardized Matricaria recutita (German chamomile) extract in the treatment of generalized anxiety disorder. Holistic Nursing Practice, 27(6), 366-368.
Sarris, J. (2018). Herbal medicines in the treatment of psychiatric disorders: 10-year updated review. Phytother Res, 32(7), 1147-1162. doi: 10.1002/ptr.6055
Sarris, J., Byrne, G. J., Bousman, C. A., Cribb, L., Savage, K. M., Holmes, O., . . . Nazareth, S. (2020). Kava for generalised anxiety disorder: A 16-week double-blind, randomised, placebo-controlled study. Australian & New Zealand Journal of Psychiatry, 54(3), 288-297.
Sarris, J., Kavanagh, D. J., Adams, J., Bone, K., & Byrne, G. (2009). Kava Anxiety Depression Spectrum Study (KADSS): A mixed methods RCT using an aqueous extract of Piper methysticum. Complement Ther Med, 17(3), 176-178.
Sarris, J., Kavanagh, D. J., Byrne, G., Bone, K., Adams, J., & Deed, G. (2009). The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. Psychopharmacology, 205(3), 399-407.
Sarris, J., Stough, C., Bousman, C. A., Wahid, Z. T., Murray, G., Teschke, R., . . . Schweitzer, I. (2013). Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. Journal of Clinical Psychopharmacology, 33(5), 643-648.
Şenel, E. (2019). Evolution of homeopathy: A scientometric analysis of global homeopathy literature between 1975 and 2017. Complement Ther Clin Pract, 34, 165-173. doi: 10.1016/j.ctcp.2018.11.018
Stub, T., Musial, F., Kristoffersen, A. A., Alræk, T., & Liu, J. (2016). Adverse effects of homeopathy, what do we know? A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med, 26, 146-163. doi: 10.1016/j.ctim.2016.03.013
Vanzeler, M. L. A. (2020). Anxiety disorders and psychological evaluation: Instruments used in Brazil. Revista Científica Multidisciplinar Núcleo do Conhecimento, 13, 110-120.
Volz, H.-P., & Kieser, M. (1997). Kava-kava extract WS 1490 versus placebo in anxiety disorders-a randomized placebo-controlled 25-week outpatient trial. Pharmacopsychiatry, 30(01), 1-5.
Walach, H., Rilling, C., & Engelke, U. (2001). Efficacy of Bach-flower remedies in test anxiety: a double-blind, placebo-controlled, randomized trial with partial crossover. Journal of Anxiety Disorders, 15(4), 359-366.
Woelk, H., Arnoldt, K., Kieser, M., & Hoerr, R. (2007). Ginkgo biloba special extract EGb 761® in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. Journal of psychiatric research, 41(6), 472-480.